产品货号：
Z18042
中文名称：
HER2/ERBB2抗体
英文名称：
Anti-HER2/ERBB2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HER2/ERBB2 Antibody |
| 指标别名 | CD340;ERBB2;HER 2;HER 2/neu;HER2;MLN 19;MLN19;NEU;NGL;p185;p185erbB2;Proto oncogene c ErbB 2;Proto oncogene Neu;TKR1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF,IP |
| 基因名称 | ERBB2 |
| 抗体来源 | Chicken |
| 抗体类型 | IgY |
| 免疫原 | erbB-2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human erbB-2.The immunogen is located within the last 50 amino acids of erbB-2. |
| 计算分子量 | 138kDa |
| 成分 | erbB-2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | erbB-2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development.Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer.ErbB-2,also known as HER2,has been implicated in the evolution of both breast and gastric cancers,and is evident in other cancer types such as ovarian and salivary gland tumors.ErbB-2 possesses an active tyrosine kinase domain,but no direct ligand has been identified yet.ErbB-2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK,PI3k-PKB/Akt,and PLC-PKC signaling pathways.Numerous anti-cancer strategies have been employed against erbB-2,such as antibody-based therapies to prevent ligand binding or receptor activation through dimerization,antibody-dependent cell mediated cytotoxicity,in addition to direct kinase inhibition to prevent molecular activation/downstream signaling. |
| Uniprot ID | P04626 |
| 基因名全称 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog |
| 蛋白名全称 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog |
| 推荐稀释比 | erbB-2 antibody can be used for detection of erbB-2 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in rat samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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